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江西省新余市远洋技术制造有限公司  
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首页 > 产品 > SR-121463A 185913-79-5
SR-121463A 185913-79-5
单价 8800.00 / 公斤
销量 暂无
发货 江西新余市付款后3天内
库存 1000公斤起订1公斤
品牌 医药中间体
cas 185913-79-5
英文 SR-121463A 185913-79-5
分子式 C17H22ClNO3
过期 长期有效
更新 2019-04-27 19:43
 
详细信息
SR-121463A  185913-79-5
价格:8800元/公斤 含量:99% 包装:25公斤
CAS;185913-79-5
分子式:C17H22ClNO3
分子量:323.8228
化学名称 N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro

[cyclohexane-1,3'-indolin]-1'-ylsulfonyl]-3-methoxybenzamide fumarate
The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives 

3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in 

THF to yield the disulfonate (III). The condensation of (III) with 5-

ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound (V), 

which is deprotected with HCl in methanol to afford the spiranic alcohol (VI). The 

oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 provides the 

spiranic cyclohexanone (VII), which is treated with 2-chloroethanol (VIII) and 

Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with zinc 

borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane yields the 

2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-butylcarbamoyl)-

2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF to afford the 

adduct (XII). Finally, the target compound is obtained by condensation of (XII) 

with morpholine (XIII) by means of NaI in DMF, followed by treatment with fumaric 

acid.

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